Total number of deaths in each category from 1999 through 2016 are shown in the upper left corner of each plot. The colors indicate age-adjusted mortality rates per 100,000 people. (Synth Opioids OTM: synthetic opioids other than methadone. This category includes fentanyl and its analogs.)
In just over two years, papers on large language models (LLMs) in medicine have accumulated nearly fifteen thousand citations, creating an academic canon that is already shaping funding decisions, regulatory conversations, and clinical experimentation. This study dissects the 100 most-cited LLM-in-medicine papers to show who is driving the field, which applications dominate attention, and where the evidence remains dangerously thin. What emerges is a picture of rapid intellectual consolidation—paired with a widening gap between technical promise and clinical reality. The...
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